Phytobiomes consist of plants, their associated communities of organisms, and their geophysical environment. Improved understanding of systems-level Phytobiome community interactions and enhanced predictive capabilities for field-based farm management are needed to advance food security and sustain a growing global population. The geophysical environment includes interactions, sensitivities, feedbacks, and constraints with respect to weather, climatic trends and events, and interdisciplinary linkages between biological aerosols, hydrology, soils, and atmospheric properties. This session focuses on analytical methodologies to explore, integrate, optimize, and apply knowledge advances within all system components, including process-level studies of interactions among components. Implicit in these approaches is the need for interdisciplinary interactions. The session will also highlight opportunities for knowledge transfer of the geophysical interactions critical to Phytobiomes in ensuring plant, soil, human and global health, including sustainable and productive agricultural systems and universal access to a safe food supply.