This is a medical biometeorological paper of a theoretical type. It explores the use of climatic pressure chambers. It places changes in pressure over time, not the actual ambient pressure, as the key. It then offers explanations of the mechanism of action both on the single cell and also multi-cellular human being. The paper relies on combined clinical experience, literature reviews and scientific studies to support the theories offered. This work also relates, the lateral line system, acupuncture and tourniquet pain to explain the underlying basis of action.