We will present a methodology based entirely on satellite remote sensing data to calibrate a hydrologic model, simulate the spatial extent of flooding, and evaluate the probability of detecting inundated areas. MODIS- and ASTER-based flood inundation maps are retrieved over the region and used to benchmark the NASA-OU CREST distributed hydrologic model simulations of streamflow and inundation areas in Lake Victoria Basin. Furthermore, Aqua AMSR-E Microwave based stream flow estimates are also used to validate the CREST model parameter transferability in the Kavango basin. The analysis has showed the applicability of integrating satellite data products as input for a distributed hydrological model as well as direct estimation of flood extent maps. The quantification of flooding spatial extent through orbital sensors can help to evaluate hydrologic models and hence potentially improve hydrologic prediction and flood management strategies in these ungauged basins. The ultimate goal is to apply the above research results to the regional operational decision-making support system SERVIR-Africa (www.servir.net).