Vulnerability, adaptation, and capacity assessments can inform prioritization of the significant research gaps in understanding and managing the health risks of a changing climate; filling these research gaps would provide policy- and decision-makers with insights to increase short- and longer-term resilience in health and other sectors. Research needs include to understand how climate and development pathways could interact to alter health risks over time at 1.5°C, 2°C, and higher degrees of warming above preindustrial; better understand upstream drivers of climate-sensitive health outcomes; project aggregate health impacts to understand the breadth and depth of challenges that may need to be managed at geographic scales of interest; project the time of emergence of changes in the geographic range and intensity of transmission of infectious diseases and other climate conditions; identify effective adaptation policies and programs; and estimate the health co-benefits of mitigation options. Engagement with other sectors is needed to ensure that their mitigation and adaptation activities also promote and protect health and take the health sector’s needs into account. Making progress in these areas is critical for protecting the health of future populations.