Understanding, modeling and predicting the weather dynamics and meteorological processes for the Gulf coastal region is important for agriculture, fisheries and forestry management as this region occupies a strategic position in the economy of the nation. Further this region can serve as a focus for understanding the natural interactions between the atmosphere, land and water. Under NOAA/NESDIS ERAISA (Environmental Risk Assessment Integrative Systems Approach) project, previous studies by Reddy et.al, 2003 and Mallikharjun Vatti & Reddy et.al 2003, provided a prototype ERAISA using GIS/RS applications for historic May 1995 Southeast Louisiana and Southern Mississippi Flood event. In the present study, we investigate a case study of 1993 Mississippi flood event using a coupled Atmospheric and Hydrological model to study surface hydrology features such as runoff, salinity etc. We apply GIS/RS tools to the model simulations for an assessment of environmental risk analysis. The results will be presented and discussed.