The purpose of this paper is to describe a procedure to optimally assimilate high-resolution AIRS profile data in a regional analysis/forecast model. The paper will focus on the impact of AIRS profiles on a rapidly developing east coast storm and will also discuss preliminary results for a 30-day forecast period, simulating a quasi-operation environment. Temperature and moisture profiles were obtained from the prototype version 5.0 EOS science team retrieval algorithm which includes explicit error information for each profile. The error profile information was used to select the highest quality temperature and moisture data for every profile location and pressure level for assimilation into the ARPS Data Analysis System (ADAS). The AIRS-enhanced analyses were used as initial fields for the Weather Research and Forecast (WRF) system used by the SPoRT project for regional weather forecast studies. The ADAS/WRF system will be run on CONUS domain with an emphasis on the east coast. The preliminary assessment of the impact of the AIRS profiles will focus on quality control issues associated with AIRS, intelligent use of the quality indicators, and forecast verification.