A set of three PTR-MS and three aerosol mass spectrometers (AMS) units were deployed between September 5-27th, 2006 to make co-located VOC/aerosol observations at the Aldine, Deer Park and Bayland Park air monitoring stations of Houston, TX. These locations were chosen based on past measurements showing very high ozone design values at these sites and strong contrasts in aerosol composition and hygroscopicity. The Deer Park site, on the southeast part of Houston, is also very close to the emission rich Houston Ship Channel. The Bayland Park site is on the southwest part of Houston and Aldine in the north-central part of the city. This paper will present a statistical overview of key observations from the PTR-MS, the AMS and ancillary meteorological observations at these sites, highlighting a) the covariance between the chemical measurements and the associated meteorology and b) statistically significant differences in these measurements at each of the three sites. We will also present estimates of ozone production efficiency and compare these estimates with values measured during the Texas 2000 Air Quality Study.