The VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REX) is an international field experiment designed to better understand physical and chemical processes central to the climate system of the Southeast Pacific (SEP) region. The climate of the SEP region is a tightly coupled system involving poorly understood interactions between the ocean, the atmosphere, and the land. Scientists from NOAA/ESRL's Physical Science Division and the North Carolina State University deployed an air-sea flux, boundary layer, and cloud/precipitation observing system for observations from the NOAA Ship Ronald H. Brown during the field phase from October 8 to November 29, 2008. The observations included direct fluxes of momentum, sensible heat, latent heat, and CO2; wind, temperature, and humidity profiles from rawinsonde; cloud microphysics from mm-wavelength Doppler radars and microwave radiometers; and mesoscale drizzle structure from a scanning C-band Doppler radar. In this paper we will present some preliminary results from these observations.