At the request of Congress, the National Academy of Sciences / National Research Council carried out a major new suite of studies to provide advice on strategies to respond to global climate change. The 'America's Climate Choices' studies included four panel reports (Advancing the Science of Climate Change; Limiting the Magnitude of Climate Change; Adapting to the Impacts of Climate Change; Informing an Effective Response to Climate Change) which together provide detailed analysis of current scientific understanding and future research needs, technology and policy options for limiting greenhouse emissions and for adapting to climate change impacts, and strategies for improving public engagement and decision support. A final report synthesizes the panel findings and recommendations and also addresses broader questions about the types of actions needed for a comprehensive, balanced national response to climate change, and the types of decision-making frameworks and processes needed for dealing with the complexities and uncertainties inherent to climate change. This presentation will offer a brief overview of the key messages from this suite of studies, and a discussion of how the studies have been disseminated and are being used (or not) by decision makers at different levels.