Moose (Alces alces) play a major role in the dynamics of boreal forest ecosystems and are an important resource for subsistence users. Fire is a major disturbance of boreal forests in interior Alaska, but how the age and juxtaposition of fires affects the density and distribution of moose on a landscape scale is poorly understood. To evaluate these effects, data collected by the Alaska Department of Fish & Game and other government agencies in interior Alaska on the early winter density and distribution of moose (2628 spatial units of approximately 15 km² each) were analyzed for relationships with spatial data on vegetation, topography, distance to rivers and towns, the occurrence and timing of fire, and a variety of landscape metrics describing patch size, shape, and configuration. Because densities vary widely due to large scale differences in management and other factors, a spatial response surface of the log of female moose density was fit and residuals were calculated so that local relationships were preserved. To examine the effects of scale, a spatial linear model was used to analyze the dependence of residuals on independent variables organized at 15, 23, 34, 51, 76, and 114 km². The analysis revealed that the densest populations of moose occur closer to towns (t=-5.04), at moderate elevations (t=5.98), near rivers (t=4.85), and in areas where fire occurred between 11 and 30 years ago ( t=3.66 for 11 to 20 years and t=3.48 for 21 to 30 years). In addition, moose tend to occur in areas that have large (t=2.12) compact (t=2.87) patches of varied habitat and avoid variable terrain (t=-2.49) and non-vegetated areas (t=-2.13). Significant relationships of most variables with moose density occurred at or below the 34 km² scale, which suggests that moose respond to environmental variables within a few kilometers of their location.