Global and regional scale simulations are conducted for a future period (2045 2055) based on predicted climatology and emissions and compared to base case simulations of a contemporary climate realization (1990 2000). For the contemporary simulations, US anthropogenic emissions are based on the National Emissions trend 1999 (NEI99) dataset, while future year anthropogenic emissions are projected using emission growth factors from EPA's the Economic Growth Analysis System (EGAS) along with the IPCC A2 business as usual scenario. Biogenic emissions are treated using the new biogenic emissions Model of Emissions of Gases and Aerosols from Nature (MEGAN). In addition, a newly developed Stochastic Fire Scenario Builder (FSB) is implemented to estimate prescribed and wild land fire emissions for the current and future scenarios. In this paper, we present an analysis of the results of contemporary and future, long term air quality simulations as a result of changes in global and regional climatology. As a way of qualifying our modeling results, air quality simulations for the contemporary period are compared with long term observations in the Pacific Northwest and Northern Midwest regions.