The patterns of general circulation of the atmosphere which determines the characteristics of global and regional climate variation will be different from what it is currently. If the current global warming persists unchecked, it may lead to significant change in global and regional climate these changes are expected to have substantial impacts on human health. The main purpose of this work is to investigate the potential impact of climatic variations in relation to human health. This research work focuses on human health diseases caused by climatic variation. This work focus on malaria and mapping of the breeding patterns as it relates malaria sickness to human health and factors of climatic variation. The climatic parameter that was used includes the average temperature, rainfall amount, and health indexes of the study area. This study investigates the factors responsible for increases or decreases in human's health in relation to climate variations. Ten years data was used for this investigation. Bivariate correlation, multiple correlation and regression analyses were conducted in this study; also (SPSS) was used to investigate the relationship between human health challenges and malaria sickness and climate variations. The climate variables used in the bivariate correlation analyses include annual and seasonal totals and monthly rainfall in Nigeria. Climate variable used in the multiple correlation and regression analyses. The preliminary result of the work shows that there is a relationship between climate variation and challenges in human's heath considering malaria as a case study. Key words: Climatic Variation, Weather, Human Health and Malaria Disease.
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