Patients & methods: It's a summary from many clinical studies performed in 3 countries -Israel, Lithuania, Azerbaijan,, comparing clinical events, laboratory data with Space Weather indices; physical data was from Space Institutions in the USA, Russia, Finland. Results: SA and GMA are related, r=0.5, p<0.0001 and inverse related to CRA SA/CRA, r=-0.85, P<0.0001, GMA/CRA r=-0.66, p<0.0001. 1.Month of birth and human pathology- victims of Sudden Cardiac Death (SCD), patients with Acute Myocardial Infarction (AMI) and , also, Cancer patients show significant differences in month of birth. 2.Timing of acute events: Acute Myocardial Infarction , Sudden Cardiac Death, Cardiac arrhythmia's , Electrical Heart Storm , Stroke show significant links by timing with CRA, SA. The culprit artery in AMI related to CRA and GMA. Deaths from Stroke are linked to CRA, SA and GMA. Many congenital lesions - Down Syndrome, Congenital Heart Disease are related to Space Whether activity, mostly in the month of conception. Blood coagulation and inflammation markers are connected with GMA and inverse to CRA. Hormone production is connected with Space Weather. 3.Gene activity and Space Weather: The Human Genome Project give a basis for homeostasis regulation. The timing of events is often related to Space physical activity. We can presume, that Gene functional activity is, partially, regulated by changing Space Weather. Conclusion: human homeostasis is affected by changing Space Weather physical activity. Different space weather components affect different human health risk factors resulting the equilibrium paradigm in clinical cosmobiology.