Under EPA Region 6 sponsorship, the PDNOS data set was used to support advanced meteorological, emission, and air quality modeling of the entire Paso Del Norte region. Given the technically complex and nonlinear factors and processes that affect ozone and CO distributions in the region, an advanced photochemical air quality grid model, CAMx, was selected for evaluation, and application. CAMx inputs were developed using output from RAMS prognostic meteorological modeling and from extensive gridded emissions modeling. The RAMS modeling is described in a companion paper. CAMx was applied using a nested-grid configuration, with horizontal grid resolutions of 4-km, 2-km, and 1-km. The periods modeled included a three-day ozone episode during August 1996, and a one-day CO episode during December 1997. This paper describes both the CO and ozone CAMx applications for the Paso Del Norte region, including many of the technical obstacles that had to be addressed, and evaluates the ozone and carbon monoxide benefits due to automotive fuel changes.