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In this context we have developed a non-Markovian closure model consisting of general expressions for the eddy-topographic force, eddy viscosity, and stochastic backscatter derived for barotropic flow over mean (single realization) topography, with and without non-Gaussian restarts. The closure is compared with ensemble averaged direct numerical simulations (DNS) for severely truncated two-dimensional Navier-Stokes flows. The model, established on the basis of a quasi-diagonal direct interaction (QDIA) closure incorporates equations for the mean vorticity, vorticity covariance and response functions, formulated for discrete spectra relevant to flows on the doubly periodic domain. This procedure allows the unambiguous comparison between the closure and the DNS as well as allowing for the incorporation of all interactions both local and non-local. A significant computational efficiency is gained via the periodic truncation of the potentially long time-history integrals where the closures are restarted using both two and three-point cumulants as new non-Gaussian initial conditions. The closures and DNS are compared in 80-day integrations employing typical meteorological time and space scales in inviscid, viscous decay and forced dissipative experiments. The closure equations demonstrate the required conservation laws in the inviscid system ie. kinetic energy and potential enstrophy, as well as satisfying the canonical equilibrium relation.