Human exposure to thermal extremes in concert with other vulnerability factors increases the risk of negative human health outcomes ranging from reduced labor productivity to death. Human biometeorology focuses on these complex interactions between weather and human health. This session solicits presentations on advances in scientific understanding and modeling of human health consequences and their causes linked to thermal extremes (such as heat waves and cold waves). We encourage abstracts focused on a mechanistic understanding of the pathways leading to such health outcomes as well as investigations into targeted interventions which may demonstrably reduce risk when implemented. We encourage consideration of both slow-evolving heat risk and adaptation as well as short-term heat risk and interventions. This session will begin with a Core Science Keynote that describes human biometeorology in extreme heat/cold environments and the spectrum of health impacts globally. The session is sponsored by the International Society of Biometeorology.