In this study, synthetic GOES-12 imagery was used to improve the two-moment prediction of pristine ice in the RAMS mesoscale model. This model was used as part of the GOES-R risk reduction activities. A thunderstorm event that occurred on 27 June 2005 over the central plains of the United States was chosen for study. Because GOES-R observations are yet to be available, synthetic GOES-12 3.9 µm imagery of RAMS output was compared to observed GOES-12 3.9 µm imagery. A discrepancy between brightness temperatures of two anvils of thunderstorms led to an improvement in the prediction of pristine ice number concentrations. After the model was re-run, subsequent synthetic GOES-12 3.9 µm imagery of one anvil exhibited a reduced discrepancy with observed imagery. The second anvil became too warm, an issue that may be related to model-specified CCN concentrations. This example highlights the potential importance of using synthetic imagery to evaluate numerical weather prediction models.