Teleconnection between precipitation rate over the Red Sea and El Nino-Southern Oscillation (ENSO) has been investigated. The NCEP/NCAR reanalysis data of annual and monthly mean precipitation rate over Red Sea, the Southern Oscillation (SO) and El-Nino3 indices for the period (1948-2005) have been used through the present study. Correlation coefficient technique, Monte Carlo, has been used to indicate the relationship between precipitation over the Red Sea and both of El-Nino3 and SOI. The results revealed that the precipitation rate in the Red Sea response to ENSO particularly over the southern part of the Red Sea region. The relationship between the precipitation rate and ENSO varied from month to month and from region to region. Whereas, it is noticed that the sign of the significant correlation values between the monthly mean precipitation and ENSO varies form month to month and from region to region through the period of study. The precipitation rate in the southern part region of the Red Sea has correlated to ENSO more that those other parts. In addition to that, it is clear that the sign of the significant correlations between the precipitation rate over the Red Sea and El-Nino3 is contradicting to SOI for almost of the months of the year during the period of study.