Recently the effects of climate change on air-quality and vice-versa are studied quite extensively. In fact, even at regional and local scale especially the impact of climate change on the atmospheric composition and photochemical smog formation conditions can be significant when expecting e.g. more frequent appearance of heat waves etc. For the purpose of qualifying and quantifying the magnitude of such effects and to study the potential of climate forcing due to atmospheric chemistry/aerosols on regional scale, the development of coupling of regional climate model and chemistry/aerosol model has been started recently on the Department of Meteorology and Environmental Protection, Faculty of Mathematics and Physics, Charles University in Prague. Regional climate simulations are calculated using model RegCM while chemistry and aerosols are solved by model CAMx. Meteorological fields generated by RegCM drive CAMx transport, dry/wet deposition as well as the chemistry of the species. A pre-processor utility was developed on the department for transforming RegCM provided fields to CAMx input fields and format. Off-line one way coupling enables the simulation of distribution of pollutants over 1991-2001 in very high resolution of 10 km as scheduled in framework of ongoing EC FP6 project CECILIA for the area of Central Europe. Validation to observational data shows reasonable improvement of the results with respect to lower resolution run at least for some stations. Simulations driven by climate change boundary conditions for time slices 1991-2000, 2041-2050 and 2091-2100 will show the effect of climate change on the air quality in the region.