Project EC FP6 CECILIA – Central and Eastern Europe Climate Change Impact and Vulnerability Assessment is studying the impact of climate change in complex topography of the Central and Eastern Europe in high resolution. The impacts on agriculture, forestry, hydrology and air-quality are studied. Resolution of regional climate simulation is an important factor affecting the accuracy of dynamical downscaling of the global changes. Especially the extremes are strongly dependent on the terrain patterns as shape of orography or land use, which can contribute to extreme temperatures or precipitation appearance. Here the reliability of the RCMs in reproducing climate conditions and extremes for targeted regions is studied in the experiment with the perfect boundary condition driving in simulations for EC FP6 project CECILIA. The results of simulation performed with the resolution of 10 km using reanalysis ERA 40 as driving fields are presented and compared with the emphasis on extreme temperature and precipitation characteristics, validation based on the station observations from the Czech Republic. The preliminary results of simulations for climate change conditions driven by ECHAM5 GCM for time slices 2021-2050 and 2071-2100 are presented as well with respect to control period 1961-1990.