NOAA/NESDIS has been inter-calibrating and reprocessing the MSU/AMSU/SSU observations onboard historical NOAA, NASA, and European MetOp-A orbiting satellite series to develop upper-air temperature climate data record (CDR). Different atmospheric layer temperature CDRs have been developed after years of effort. These CDRs include i) STAR Version 2.0 MSU/AMSU layer temperatures of mid-troposphere, upper troposphere, and lower-stratosphere; ii) STAR Version 1.0 SSU layer temperatures of mid-stratosphere, upper-stratosphere, and top-stratosphere. These are monthly gridded data with 2.5 latitudes by 2.5 longitudes. The MSU/AMSU CDR covers the period from 1979 to present and the SSU CDR is from 1979 to 2007. These datasets are currently being used for assessment of upper-air temperature climate change. This presentation will review the science issues involved in developing these time series, including inter-satellite calibration using simultaneous nadir overpasses to remove instrument specific errors, diurnal drift corrections, SSU gas leaking problems in its CO2 cell, etc. We will introduce 30+years cross-calibrated MSU/AMSU radiance fundamental climate data records for reanalysis applications. Finally, we will present a comprehensive review on the global atmospheric temperature trends from the mid-troposphere to the upper stratosphere derived from MSU/AMSU/SSU observations.