Since the launch of the TIROS-N satellite on October 13, 1978, NOAA has been leading for operational calibration of the instruments on board the polar-orbiting satellites. An enterprise approach has been proposed and developed since the launch of NOAA-15 satellite in 1998. Prior to each new NOAA launch, prelaunch TVAC data is analyzed for our independent assessments on key instrument performance. During the intensive calval period, a high quality level-1b radiance data are delivered for applications at NOAA and other centrals. The state-of-the art calibration algorithms are developed, tested and implemented for operation, including lunar calibration and correction models, correction for instrument sudden jumps, simultaneous nadir over-passing (SNO) for cross-calibration, and double difference using forward model and deep convective clouds (DCC), etc. NOAA scientists has been working closely with the international community through WMO GSICS and CEOS Working Group CalVal (WGCV) and developing the best practices for instrument calibration. These operational calibration components are now further enhanced for NPP and JPSS missions. This presentation will be focusing on NOAA operational calibration support for NPP/JPSS instruments (e.g. CrIS, VIIRS, ATMS and OMPS) and long-term monitoring systems for trending the instrument performance and charactering the instrument biases with respect to other operational sensors and NWP simulations.