The overarching mission of the Climate and Environmental Sciences Division within the U.S. Department of Energy is to advance a robust predictive understanding of Earth’s climate and environmental systems, including the interactions of human and natural systems and the implications for energy systems. A rapidly growing area of research interest at DOE is the integrated regional water cycle encompassing atmospheric, ground, and surface water; projected energy and other human and natural demands under future possible climate states; and land-use and hydro-climate feedbacks. This town hall will serve as a means for discussing DOE’s research priorities on the regional integrated water cycle. For additional information, please contact Patrick Horan (e-mail: patrick.horan@science.doe.gov).