In this work we examine variations in aerosol loading over the eastern seaboard of the United States and the North Atlantic Ocean from 2000 to 2012. This period is significant due to anthropogenic emissions control measures that are in place. We use monthly mean data from satellite (MODIS), ground (AERONET, IMPROVE), and model (GOCART) sources. From MODIS observations, a statistically significant -0.020 decade-1 trend in aerosol optical depth (AOD) over the mid-latitudes is seen. Correlation of AOD between MODIS and AERONET sites in the upwind regions as well as trend analysis of GOCART component AOD reveal the anthropogenic origin of this trend downwind of the eastern U.S. IMPROVE network surface PM2.5 observations from the eastern U.S. confirm statistically significant decreases in total PM2.5 driven primarily by decreases in anthropogenic PM2.5 species. In contrast to the mid-latitudes, MODIS observations reveal a statistically significant 0.015 decade-1 trend in AOD over the sub-tropics. AERONET correlation, GOCART component trends, and an estimation of summertime dust flux suggest that this trend is of natural origin. Finally, preliminary results are presented for both aerosol direct and indirect effects. This work offers an assessment of aerosol trends and aerosol-cloud interactions in the context of decreasing anthropogenic aerosol contribution and on timescales relevant to climate processes.