The national projects increased resilience to changes in the geographic range and incidence of infectious diseases by focusing on incremental improvements in policies and programs to address climate variability, and by beginning to establish enabling environments for additional adaptation. Irrespective of resource constraints, low and middle-income countries need to prepare for climate change through better understanding of potential risks, strengthening health systems, ensuring adequate policies and legislation, facilitating institutional support, and public education and awareness programs, including disaster preparedness measures. However, no project planned nor considered how to scale up activities to improve surveillance and other programs to manage the risks of infectious diseases in a changing climate. National health plans need to move beyond focusing on climate variability to transforming adaptation into multi-faceted, collaborative, and iterative programs incorporating longer-term climate change.