The Sixth Conference on Transition of Research to Operations (6R2O) will hold a panel discussion on Considerations and Best Practices for Transition of Research to Operations along the theme of connecting research to societal benefits. The panel will be composed of leaders in R2O from government, academia, and industry. The panel of experts will each make a brief presentation on their experience with R2O leadership and their understanding of best practices. Many challenges are common to R2O programs across sectors, and best practices from one agency will likely prove applicable in another. Funding is a well known challenge, and frequently cited as the limitation, but often is only part of a solution in combination with other factors such as coordinating policies and process to support transition. Many of the most successful institutes or companies relative to R2O cultivate a culture of transition with close ties and good communication between their research teams and operations teams. Our panel of experts will present their lessons learned and best practices for successful transition across agencies, sectors, and operational scales.