Multi-vehicle crashes occurring along I-80 in Wyoming have resulted in loss of life, extended road closures, and direct impacts on the nation’s economy. Blowing snow, high winds, wildfires, and poor visibility all contribute to the challenges of keeping I-80 open and safe for both passenger and commercial traffic. To address these safety and mobility concerns, the Wyoming CV Pilot Deployment team is developing a system of CV-based applications to collect, process, and disseminate vehicle and environmental data and alerts to drivers, commercial truck dispatchers, the Transportation Management Center (TMC), and other stakeholders. Data will be collected from about 400 vehicles via 75 roadside units on I-80, processed through the Pikalert Vehicle Data Translator and Road Weather Hazard module, and used by the TMC and in 5 in-vehicle applications: Forward Collision Warning, Situational Awareness, Distress Notification, Work Zone Warning, and Spot Weather Impact Warning. The pilot deployment is expected to improve situational awareness and actionable information available to WYDOT and I-80 travelers, provide WYDOT with an operational CV system that will continue beyond the timeline of the project, and is hoped to reduce the number and severity of multi-vehicle crashes on I-80. This presentation describes the challenges faced in the Wyoming environment, the CV Pilot Deployment plan, and the current status of application development.