Developing predictive capacity for health outcomes resulting from extreme heat events requires an integrated understanding of the social, physiological, epidemiological, and climatological mechanisms that drive health outcomes for individuals and subpopulations. This session will explore the interaction of these mechanisms and the various research methods for understanding them. Research, observations, and information needs from the climate, meteorology, and epidemiology communities to support public health, emergency management, urban planners, and other professionals will be a focus of this session.