The Naval Research Laboratory has recently extended its scalable, FAST3D Computational Fluid Dynamics model to contaminant transport problems for urban and environmental hazard assessment. FAST3D is flow solver for three-dimensional, time-dependent, compressible reactive flow problems. The underlying fluid dynamics algorithm is the Flux-Corrected Transport algorithm, which is a high resolution, direction split, monotone, conservative, positivity-preserving algorithm. Turbulence is modeled through the Large Eddy Simulation method MILES, in which subgrid effects are accounted for implicitly by the non-linear flux limiting of the algorithm. Of particular interest to unsteady numerical applications is understanding how to realistically simulate atmospheric wind so that the resulting flow patterns around buildings are accurately described. In previous work, computational modeling of such effects was investigated in a validation study of flow over a surface-mounted cube. In this paper, we investigate the effects of inflow velocity characteristics on flow patterns around a complex full-scale building through a series of calibration studies using field test data and numerical sensitivity studies. Computational velocity fields are compared with both steady (i.e., statistically averaged) and high-frequency field measurements to help calibrate the model. Sensitivity studies are performed to assess the relative effects of wind input patterns and grid resolution on simulation accuracy. Simulations with and without neighboring trees are contrasted to highlight the importance of modeling their dissipative effects.