The use of GIS, combined with new types of advanced and localized meteorological data sets, can be used to solve a wide range of complex business related weather issues. Examples include improved fleet transportation routing efficiencies, more accurate energy industry load forecasting, precise analysis of hurricane damage potential, enhanced public safety with lightning monitoring, water district management, flash flood forecasting, and improved emergency response to possible airborne bio-terrorist attack. The unique combination of GIS with appropriate meteorological data sets produces intriguing synergies and possibilities for improved problem solving in the future.