This study evaluates the hypothesis that mesoscale uncertainty associated with the WCB plays an outsized role in introducing downstream forecast errors along the midlatitude waveguide. The above hypothesis is evaluated by applying the ensemble-based sensitivity technique to Model for Prediction Across Scales (MPAS) ensemble forecasts of select North Atlantic cyclones characterized by a significant waveguide perturbation. This hypothesis is assessed by comparing the sensitivity of downstream forecasts to the divergent outflow as well as other features, such as the position of upstream troughs or details of the waveguide itself. Finally, the role of mesoscale thermodynamic and kinematic uncertainty on waveguide perturbation structure will also be quantified by computing the sensitivity of the waveguide perturbation to lower-tropospheric relative humidity, temperature, and horizontal wind within the WCB.