The analysis involves a number of assumptions such as the statistical model used, the effects of regional averages (such as from satellites), the limitations of sampling, etc. A number of these assumptions have been tested and the results will be explained. In general, the largest uncertainty in this analysis is often due to our limitations in estimating future trends in the environment.
This type of analysis can be helpful for a number of reasons. With a number of atmospheric factors expected to change in the future, it is useful to understand which are likely to show statistically significant trends earliest. For individual parameters, choosing optimal monitoring locations will allow for earlier detection of environmental changes. Optimal monitoring will also allow for scientific questions to be answered earlier and adjustments in our understanding based on the monitoring results. Programmatically, it is useful to establish reasonable expectations for how long it will take to detect the expected trends. Changes in location and number of monitoring sites as well as calibration procedures can be justified in terms of number of years saved in the detection of change.