Previous studies have shown that the ionosphere’s response to solar eclipses has a distinct latitudinal dependence. The response of the low-latitude and equatorial ionosphere is more intense and may be quite different from the middle latitude ionosphere response. In addition, theoretical calculations show that when the eclipse takes place in the Northern Hemisphere, a small ionospheric disturbance also appeared in the conjugate hemisphere, indicating importance of dynamical processes. Simulations suggest that most of the observed differences in the behavior of NmF2 during eclipses (solar zenith angle, local time, and dip angle effects) can be attributed to differences in O+ loss rate related to background differences in neutral molecular densities. Our observations provide essential data to test these hypotheses and provide a comprehensive view of changes in the near-Earth space environment induced by solar eclipse.