This presentation describes recent advances in our understanding of lake-effect systems and their modification by orography. It draws on findings derived from the Ontario Winter Lake-effect Systems (OWLeS) field campaign, radar-based climatologies from the Tug Hill Plateau of upstate New York and the Hokuriku region of Japan, space-borne remote sensing, real-data mesoscale modeling, and idealized cloud modeling. These multiple lines of inquiry highlight the importance of coastline geometry in organizing lake-effect systems and illustrate how the inland penetration and orographic enhancement of lake-effect precipitation is modified by the characteristics of the incident flow, mode of the lake-effect system, and shape and size of the downstream terrain. The implications of these findings for existing conceptual models of lake-effect systems and their interaction with orography, operational forecasting, and our understanding of extreme snowfall produced by lake-effect and orographic processes will be examined.