In this presentation, we demonstrate how QUIPU and in situ data collection offer potential to improve the interpretation of sub-seasonal to annual isotope signals preserved in low-latitude ice cores. In July 2017 our joint US-Peru-Bolivia team obtained snow pit isotope profiles from four high Andean summits at elevations between 5,670-6,265 m ASL along a 450 km linear transect (Quelccaya, Peru and Nevados Ancohuma, Huayna Potosi and Illimani, Bolivia). Storm precipitation amount and isotopic content measurements, collected daily at additional 10 sites in Peru and Bolivia by citizen scientist observers and processed through QUIPU, provide date-specific age models for each snowpit profile. The QUIPU simulations demonstrate skill at accurately reproducing high and low frequency δ18O signals and amplitudes observed in annual accumulation profiles. As such, QUIPU is enabling determination of the controls on δ18O annual layer profiles by meteorological phenomena under modern climatic conditions; this in turn informs interpretation of the climatic conditions associated with older δ18O registered prior to the instrumental era and retrievable in ice core records.